P108
Sigma
N6-Phenyladenosine
solid
| Linear Formula: | C16H17N5O4 |
| Molecular Weight: | 343.34 |
| MDL number: | MFCD00055129 |
| PubChem Substance ID: | 24277728 |
Description
| Biochem/physiol Actions | Potent A1 adenosine receptor agonist |
Properties
| form | solid |
| potency | 4.6 nM IC 50: A1 (A2 = 660 nM) |
| color | white |
| mp | 187-188 °C(lit.) |
| solubility | 0.1 M NaOH: soluble |
| water, ethanol: moderately soluble | |
| Gene Information | human ... ADORA1(134) |
| rat ... Adora1(29290), Adora2a(25369) |
Safety
| Personal Protective Equipment | Eyeshields, Gloves, type N95 (US), type P1 (EN143) respirator filter |
| WGK Germany | 3 |
References
| reference | Kwartra et al., N6-Phenyladenosines; pronounced effect of phenyl substituents on affinity for A2 adenosine receptors. J. Med. Chem. 30, 954, (1987) Abstract |
| Dunwiddie, et al., Adenosine analogs mediating depressant effects of synaptic transmission in rat hippocampus: Structure-activity relationships for the N6 subregion. Naunyn Schmiedebergs Arch. Pharmacol. 334, 77, (1986) Abstract |
